I wasn't that interested in this after the very average DS outing for Wario, but this looks like a return to form for the Wario Land series. 2D gameplay, decent wii remote integration and heavily stylised graphics = this game is sold to me.
Video here:
http://press.nintendo.com/E32008/wii/video_WarioLandShake_Footage.zipHopefully this won't take forever to come out here.
[Edit] Btw other than this it was a pretty average/boring E3 showing this year, although the Wii motion thing looks pretty cool and it'll be interesting to see how it develops.